Study shows daily multivitamin use may slow cognitive aging for older adults
IMAGE: ALZHEIMER'S ASSOCIATION LOGO view more
CREDIT: CREDIT ALZHEIMER'S ASSOCIATION
Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association has published “Effects of cocoa extract and a multivitamin on cognitive function: a randomized clinical trial.” The three-year study of more than 2,200 older adults found that daily multivitamin-mineral supplementation resulted in a statistically significant cognitive benefit. Cocoa extract had no effect on global cognition.
Post-embargo, the article will be at: https://alz-journals.onlinelibrary.wiley.com/journal/15525279
Advance embargoed copies are available.
Alzheimer’s Association scientists are available to discuss:
- The conduct and results of this new clinical trial.
- The implications of this announcement for public health, older adults, and people living with –-- and at risk for –-- Alzheimer’s and all other dementia, and their families.
- The Association’s perspective on Alzheimer's/dementia risk reduction, research and treatment.
Contact media@alz.org to set up an interview.
For the most recent Alzheimer’s Disease Facts and Figures, please visit alz.org/facts.
The Alzheimer’s Association is available anytime, day or night for individuals with Alzheimer’s disease and their caregivers at 800-272-3900, and info@alz.org.
Quotes from Maria C. Carrillo, Ph.D., Alzheimer’s Association chief science officer
“This is the first positive, large-scale, long-term study to show that multivitamin-mineral supplementation for older adults may slow cognitive aging. While the Alzheimer’s Association is encouraged by these results, we are not ready to recommend widespread use of a multivitamin supplement to reduce risk of cognitive decline in older adults.”
“Independent confirmatory studies are needed in larger, more diverse study populations. It is critical that future treatments and preventions are effective in all populations.”
“For now, and until there is more data, people should talk with their health care providers about the benefits and risks of all dietary supplements, including multivitamins.”
“We envision a future where there are multiple treatments and risk reduction strategies available that address cognitive aging and dementia in multiple ways — like heart disease and cancer — and that can be combined into powerful combination therapies… in conjunction with brain-healthy guidelines for lifestyle factors like diet and physical activity.”
JOURNAL
Alzheimer s & Dementia
ARTICLE TITLE
Effects of cocoa extract and a multivitamin on cognitive function: a randomized clinical trial
ARTICLE PUBLICATION DATE
14-Sep-2022
Daily multivitamin may improve cognition and possibly protect against decline
IMAGE: LAURA D. BAKER, PH.D., PROFESSOR OF GERONTOLOGY AND GERIATRIC MEDICINE AT WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE, LED THE COSMOS-MIND TRIAL, WHICH SHOWS TAKING A DAILY SUPPLEMENT MAY IMPROVE COGNITION IN OLDER ADULTS. view more
CREDIT: WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE
WINSTON-SALEM, N.C. – Sept. 14, 2022 – Could taking a daily multivitamin help maintain cognitive health with aging and possibly prevent cognitive decline? According to new research from Wake Forest University School of Medicine, conducted in collaboration with Brigham and Women’s Hospital in Boston, taking a daily supplement may improve cognition in older adults, but additional studies are needed to confirm these findings before any health recommendations are made. The study also showed that daily use of a cocoa extract supplement does not benefit cognition.
The findings were recently published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
According to the Alzheimer’s Association, more than 6.5 million Americans are living with Alzheimer’s disease, and 1 in 3 seniors die with the disease or another form of dementia.
“There’s an urgent need for safe and affordable interventions to protect cognition against decline in older adults,” said Laura D. Baker, Ph.D., professor of gerontology and geriatric medicine at Wake Forest University School of Medicine and co-principal investigator of the trial, along with Mark Espeland, Ph.D., professor of gerontology and geriatric medicine at Wake Forest University School of Medicine.
The COcoa Supplement and Multivitamin Outcomes Study for the Mind (COSMOS-Mind), funded by the National Institute on Aging of the National Institutes of Health, was an ancillary study to the COSMOS trial led by Brigham and Women’s Hospital that randomized 21,442 men and women across the U.S. The study investigated whether taking a daily cocoa extract supplement or a daily multivitamin-mineral supplement reduces the risk of developing heart disease, stroke, cancer and other health outcomes.
According to Baker, cocoa extract is rich in compounds called flavanols, and past research suggests that these compounds may positively impact cognition. Baker also said that several micronutrients and minerals are needed to support normal body and brain function, and deficiencies in older adults may increase the risk for cognitive decline and dementia.
In COSMOS-Mind, researchers tested whether daily administration of cocoa extract versus placebo and a multivitamin-mineral versus placebo improved cognition in older adults. More than 2,200 participants, ages 65 and older, enrolled and were followed for three years. Participants completed tests over the telephone at baseline and annually to evaluate memory and other cognitive abilities.
“Our study showed that although cocoa extract did not affect cognition, daily multivitamin-mineral supplementation resulted in statistically significant cognitive improvement,” Baker said. “This is the first evidence of cognitive benefit in a large longer-term study of multivitamin supplementation in older adults.”
The researchers estimated that three years of multivitamin supplementation roughly translated to a 60% slowing of cognitive decline (about 1.8 years). The benefits were relatively more pronounced in participants with significant cardiovascular disease, which is important because these individuals are already at increased risk for cognitive impairment and decline.
“It’s too early to recommend daily multivitamin supplementation to prevent cognitive decline,” Baker said. “While these preliminary findings are promising, additional research is needed in a larger and more diverse group of people. Also, we still have work to do to better understand why the multivitamin might benefit cognition in older adults.”
The COcoa Supplement and Multivitamin Outcomes Study (COSMOS) is supported by an investigator-initiated grant from Mars Edge, a segment of Mars dedicated to nutrition research and products, which included infrastructure support and the donation of study pills and packaging. Haleon provided support through the partial provision of study pills and packaging. COSMOS is also supported in part by grants AG050657, AG071611, EY025623 and HL157665 from the National Institutes of Health, Bethesda, Md. The Women’s Health Initiative (WHI) program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, 75N92021D00005. Neither Mars Edge nor Haleon provided input regarding data analyses, interpretation of results or manuscript development.
JOURNAL
Alzheimer s & Dementia
METHOD OF RESEARCH
Randomized controlled/clinical trial
SUBJECT OF RESEARCH
People
ARTICLE TITLE
Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial
ARTICLE PUBLICATION DATE
14-Sep-2022
No comments:
Post a Comment