Yeast and electricity convert CO₂ into valuable chemicals
Researchers develop a new process that captures CO₂ and produces a valuable bio-based chemical
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This study demonstrates a novel hybrid system that integrates electrochemical CO2 reduction with microbial biosynthesis of a valuable chemical in a single reactor.
view moreCredit: Izadi et al. Angew. Chemie / Graphic: Simone Bachleitner, Paniz Izadi
Itaconic acid is a bio-based organic acid used to manufacture biodegradable plastics, textiles, adhesives, and resins. It is considered a promising sustainable alternative to petroleum-based chemicals. Worldwide, around 70,000 t of itaconic acid are produced annually, and production is increasing. “On an industrial scale, itaconic acid is produced biotechnologically from sugar using a fungus. We have now developed a process that uses CO₂ instead of sugar as a starting material so that we can put emissions to productive use”, explains Prof. Falk Harnisch, an electrobiotechnologist at the UFZ and last author of the study.
In collaboration with researchers from BOKU University in Vienna, the UFZ team has developed a method that combines electrochemical and microbial processes in a single bioreactor. But how exactly does this electrobioreactor work? And how did the researchers come up with the idea of combining the use of CO₂ with the production of itaconic acid in the first place?
A previous study by BOKU University showed that itaconic acid can be produced biotechnologically from methanol, a type of alcohol. Because microorganisms can metabolise a wide range of substances, the team led by Harnisch tested a chemically similar substance that can be produced relatively easily from CO₂. “Electricity, ideally from renewable sources, can be used to convert CO₂ into formate, which is chemically related to methanol because both contain just one carbon atom. We therefore wanted to investigate whether the yeast could also use formate as an energy source for itaconic acid production”, says Dr Paniz Izadi, a researcher in Harnisch’s UFZ team and first author of the study.
The design of the electrobioreactor in which electrochemical and microbial processes take place simultaneously presented a number of challenges. The electrochemical conversion of CO₂ into formate works best at elevated temperatures and an alkaline pH in the presence of as few other chemical substances as possible. The genetically engineered yeast strain Komagataella phaffii, which is used in the bioreactor, requires entirely different conditions: temperatures of around 30°C, a neutral pH, and a nutrient-rich medium. “In order to ensure that both the electrochemical and microbial processes took place and operated as efficiently as possible, we had to find a compromise between their different requirements in the electrobioreactor”, explains Dr Simone Bachleitner, Senior Scientist at the Institute of Microbiology and Microbial Biotechnology at BOKU University.
The experiment was successful, and the yeast produced itaconic acid from CO₂ using electrochemically produced formate as an energy source. “We successfully combined electrochemical and microbial processes in our bioreactor. A self-contained process chain offers major practical advantages because it eliminates the need to transport intermediate products between separate facilities. Although the yield of itaconic acid was lower than when sugar or methanol was used, our study clearly demonstrates that CO₂ can be converted into complex and valuable biochemicals”, says Harnisch.
The researchers hope that their new process will provide a model for practical applications and contribute to the development of industrial-scale facilities. The researchers now plan to optimise the processes in the electrobioreactor and investigate their suitability for other microorganisms and bio-based products.
Journal
Angewandte Chemie
Method of Research
Experimental study
Article Title
Integrated electromicrobial production of itaconic acid from CO2 at liter-scale using Komagataella phaffii
Article Publication Date
27-Oct-2026
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