Longer meal intervals linked to faster disease accumulation in older adults
Karolinska Institutet
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Adrián Carballo Casla
view moreCredit: Photo: Maria Yohuang
Older adults who typically had longer intervals between meals accumulated chronic diseases more rapidly over time than those with shorter intervals, according to a study from Karolinska Institutet published in the Journal of Internal Medicine. The association was most pronounced among people aged 78 years and older.
Interest in fasting has increased in recent years, but relatively little is known about how meal timing affects health in older adults. In this new study, researchers investigated whether the duration of the longest daily interval between meals was associated with the accumulation of chronic diseases over time.
The researchers used data from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K), which includes 2,981 people in Stockholm who were aged 60 years or older at the start of the study. Participants were followed for up to 15 years. The duration of intervals between meals was estimated from participants’ self-reported information about when they typically ate during a 24-hour period.
Association seen across disease types
Longer intervals between meals were associated with faster accumulation of chronic diseases over time. In particular, people whose longest interval between meals during a typical day was 14 to 24 hours accumulated chronic diseases more rapidly than those whose longest interval was 6 to 11.5 hours. The association was observed for the total number of chronic diseases, as well as for cardiovascular and neuropsychiatric diseases, but not for musculoskeletal diseases.
“Much of the research on fasting has been conducted in younger or middle-aged populations. Our findings suggest that the associations may be different in older adults, particularly among the oldest age groups”, says Adrián Carballo Casla, last author of the study and postdoctoral researcher at the Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet.
The researchers emphasise that the study cannot determine cause and effect. Although longer intervals between meals were linked to faster disease accumulation, the study cannot establish whether the fasting pattern independently contributed to this outcome.
For information on funding and any potential conflicts of interest, please see the study.
Publication: “Habitual fasting duration and accelerated multimorbidity in older adults”, Luis Kalmbach, David Abbad-Gomez, Giorgi Beridze, Fernando Rodríguez-Artalejo, Davide Liborio Vetrano, Amaia Calderón-Larrañaga, Adrián Carballo-Casla, Journal of Internal Medicine, online August 20, 2026, doi: 10.1111/joim.70150
Journal
Journal of Internal Medicine
Method of Research
Observational study
Subject of Research
People
Article Title
“Habitual fasting duration and accelerated multimorbidity in older adults”
Article Publication Date
20-Aug-2026
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